G. De Paoli^a, M. Trettene^a, J.P. Pascali^a, M. Trevisan^b, F. Bortolotti^a, F. Tagliaro<sup>a

a</sup> Dipartimento di Medicina e Sanità Pubblica, Sezione di Medicina Legale, Università di Verona, Policlinico, Verona
^bUnità Operativa Autonoma di Laboratorio, ULSS 20, Verona

Currently the determination of CDT is performed using commercial kit based on extraction of CDT isoforms onto anion exchange disposable cartridges followed by a immunoassay of the eluates. In addition instrumental methods are available including isoelectric focusing, anion exchange liquid chromatography, mass spectrometry and recently capillary electrophoresis. The aim of the present work was to present a brief review of the analytical methods for CDT determination and to carry out a comparison between the results obtained with a commercial immunoassay and those obtained with a capillary electrophoretic method previously validated by our group. Methods: Serum samples from 120 subjects with different alcohol consumption have been analyzed with the immunoassay %CDT-TIA (Axis Shield) in parallel with capillary electrophoresis.