The European Union countries are characterised by a health condition typical of industrialised countries: an elderly population, the prevalence of cardiological, neurological, oncological and some infectious diseases, etc. The non-EU countries of the Mediterranean area are characterised by a health situation falling somewhere between those of developing and industrialised countries: i.e. there is a prevalence of infectious diseases, but also an incidence of diseases typical of an ageing population (oncological, cardiological, neurological, etc.); even though pediatric and new-born patients are still more commonly affected. Moreover, it is also necessary to consider the no less relevant aspect of large-scale immigrant movements, which means that many European hospitals now have to contend with diseases typical of North Africa; another factor for the medical cooperation is the increasing flow of European tourists and workers also towards the not- European countries of the Mediterranean Area.

Every approach to handling automation is beset with unique limitations. For instance, in the symbolic (rule based) approach, the brittleness of rules leads to the ineffectiveness of handling noisy data, but it derives its strengths in heuristic search. In the same vein, a case based reasoning paradigm is bedeviled with retrieval and adaptation problem. Neural network methodology suffers from its intolerance of incremental insertion of new knowledge, but triumphs over others when it comes to adaptation using its generalization characteristics. Based on all these, a tight coupling of case base, rule base and neural network methodologies is proposed for medical diagnosis and therapy. A case of hepatitis is presented with data collected from a hospital in Nigeria order to demonstrate the functionality of the system. The results of the study show that the multi-layer perceptron neural network performed better than rule based system and case based system. However, a hybridization using the three technologies produces a more accurate classification/diagnosis.

Telehealth is the use of medical information exchanged from one site to another via electronic communications to improve patients' health status. Videoconferencing, transmission of still images, e-health including patient portals, remote monitoring of vital signs, continuing medical education and nursing call centers are all considered part of telemedicine and telehealth. TCP/IP-Telehealth removes distances and waiting times, thus reducing costs, while ensuring high quality digital information even for complex health services. Telemedicine has been experimented in many countries, also in those with less advanced sanitary systems, and it is affirmed on a large scale, as ordinary component of the health services. In the past, the costs for equipment and telecommunications have been too high to allow it, and, until today, the lack of specialized personnel of support to retrieve such equipment has been another major obstacle. Figure 1. Telemedicine Integration Telemedicine represents only an aspect of Informatics use in the sanitary services. Its application is simpler and reaches better results if coordinated with the other applications.

In the current work, Mutated Rules for Sequential Mining (MRS), an efficient evolutionary sequential pattern mining algorithm, is proposed for mining DNA sequences. MRS applies mutation genetic operator to generate new rules in the population. Pruning redundant rules, MRS efficiently get the new frequent patterns which will be mutated to iteratively generate new rules in the next population. Moreover, MRS does not apply database projection for mining, with high CPU,and memory utilization. However, in order to handle variants length of sequences without alignment, MRS is modified (MMRS) to handle sequences of variants lengths. MMRS outperforms MRS and Apriori algorithms when applied to DNA sequences from GENBANK when testing three main issues: number of bases per sequence, support threshold, and number of sequences in each trial.
With the completeness of several genome projects, the number of DNA sequences has tremendously enlarged, which requires more complex techniques to be developed. The biggest excitement currently lies with the availability of complete genome sequences for different organisms.

Telepathology is the practice of pathology at distance viewing images on a monitor rather than directly through a light microscope. Telepathology Technologies included Static & Dynamic forms. This technology can be used in: Primary diagnosis, Second opinion, Quality assurance, Proficiency testing & Distance learning. To create a telemedicine channel between Italy & Egypt we began by signing a protocol of cooperation between the CIVICO hospital in Palermo & The Italian Hospital in Cairo and training of the ITmanager of the Italian Hospital in Cairo in Palermo for two weeks. Our project was divided into four phases: Telepathology, Tele-echocardiography, Tele-radiology & Tele-Endoscopy. For the First phase , We evaluated of the costs and find a fund for this, searched for the best instruments in the Egyptian market with the highest qualifications, downloaded the same software that was used in Pittsburg and Palermo and began of the connection.

A web-based Geographic Information System (GIS) has been recently implemented for the surveillance of bluetongue a vector-borne animal disease transmitted by insects of the genus Culicoides (Diptera, Ceratopogonidae). This surveillance network was part of a one year long cooperation project involving several Balkan countries. A disease transmitted by flying insects, like BT, is a transboundary problem and cannot be prevented through individual national measures and animal trade control policy only. Since other vector-borne diseases are periodically detected in the Mediterranean Basin (such as West Nile Fever) or are emerging zoonoses endangering the Mediterranean area (such as Crimean-Congo hemorrhagic fever), the Italian Ministry of Foreign Affairs in collaboration with the Abruzzo Region decided to fund a further project both to strengthen the BT surveillance network, and to extend it to these two emerging and zoonotic diseases in Balkan and Eastern Mediterranean countries. The web site, with multi-user access, will be easily accessed by a generic Internet browser.