Alexey Zhuchkov, Nikolay Tverdokhlebov, Boris Alperovich, Alexander Kravchenko

The paper describes XML-based meta-models and software services intended to search, collect and aggregate data of drug clinical usage. These tools and information structures enable detailed and actual information accumulation about possible adverse events related to drug administration to support the evidence-based pharmacology. Gridtechnology provides environment to implement services using multi-agent system technology and to operate with distributed and loosely coupled data and metadata in a transparent way. Keywords. Data management, clinical data, gridservice, XML meta-model Information about drug usage in everyday clinical practice is being accumulating in many sources all over the world. These are public sources (webpages and public services like MedLine) and private ones (databases of information systems of hospitals, pharmaceutical companies and universities).